See Amino acid for the p K a values of all amino acid side chains inferred in such a way. The p K a values of an amino acid side chain in solution is typically inferred from the p K a values of model compounds (compounds that are similar to the side chains of amino acids). The pH-dependence of the activity displayed by enzymes and the pH-dependence of protein stability, for example, are properties that are determined by the p K a values of amino acid side chains. P K a values of amino acid side chains play an important role in defining the pH-dependent characteristics of a protein.
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